01
Heritage
A 2010 discovery at Tohoku University by Prof. Mari Dezawa, and the patented manufacturing method that bears her name.
Official partner in MexicoDEZAWAMUSE CELLS®
Multilineage-differentiating Stress-Enduring cells
A cell technology discovered in Japan: stem cells with the natural ability to home in on damaged tissue and contribute to its repair.
2010Tohoku University, Japan
10+ yearsof scientific research
3germ lineages
The film
Regenerating life from its origin.
The story of Muse Cells, told by Muse Cell Innovations, the creators of the technology.
Official film · Muse Cell InnovationsSpanish version
What they are
What if the power to heal ourselves were already within us?
MUSE
Multilineage-differentiating Stress-Enduring cellsStress-enduring cells, able to differentiate into multiple lineages.
The DEZAWA MUSE CELLS® represent a significant advance in regenerative medicine. Discovered by Prof. Mari Dezawa in Japan, these unique stem cells have the natural ability to home in on damaged tissue, respond to damage signals and differentiate into cells of the affected tissue.
With more than a decade of scientific research, they are being evaluated in clinical trials in acute myocardial infarction, ischemic stroke, epidermolysis bullosa and spinal cord injury, among other indications.
No genetic reprogramming required
No teratoma formation in animal models
In clinical trials, given without HLA matching or immunosuppressants
History
From an unexpected finding to a new era.
Prof. Mari DezawaTohoku University, Japan · Discoverer of Muse Cells
2007
An unexpected finding
In Prof. Mari Dezawa's laboratory at Tohoku University, a group of cells was identified by accident within mesenchymal cells (MSCs), able to withstand severe stress and differentiate into multiple lineages.
2010
The discovery is formalized
They are described as SSEA-3-positive cells able to differentiate into all three germ layers, with no teratoma formation in animal models.
SSEA-3⁺ · PluripotentMCI
DEZAWA MUSE CELLS™ are born
MUSECell Innovations™ introduces them as DEZAWA MUSE CELLS™, in honor of their discoverer, with a licensed manufacturing method.
Today
Regene Global, in Mexico
Regene Global is Muse Cell Innovations' official partner in Mexico, bringing this technology to physicians and patients across the country.
Official partner in MexicoThe Dezawa standard
Heritage, method, verification.
A discovery from Tohoku University, the licensed method that bears its discoverer's name, and a Certificate of Analysis behind every vial.
02
Method
The Dezawa Method™: a licensed manufacturing protocol protected by intellectual property. SSEA-3+verification. Validated potency, purity and clinical reproducibility.
03
Verification
Dezawa-Verified™: every vial comes with a Certificate of Analysis from an MCI-authorized laboratory, with lot traceability and a verified chain of custody.
Science
What makes them unique.
Five properties that set Muse Cells apart from any other stem cell.
Pluripotency with low tumorigenic potential
They differentiate into all three germ layers and, unlike embryonic stem cells or iPSCs, did not form teratomas in animal studies.
Selective migration
They express the S1PR2 receptor, which lets them detect the S1P (sphingosine-1-phosphate) signal from damaged tissue. In animal models they homed preferentially to the injured area, while other MSCs were retained in the lungs to a greater extent.
Stress resistance
They withstand extreme conditions such as hypoxia, serum deprivation or prolonged incubation, which allows them to be isolated without prior labeling.
Phagocytosis and differentiation
They phagocytose damaged or apoptotic cells and receive factors from them that can induce their differentiation into the tissue’s cell type.
Immune modulation
They express HLA-G, a molecule associated with immune tolerance. In clinical trials, donor cells have been given without HLA matching or immunosuppressants.
How they work
From the source tissue to the repaired tissue.
01/ 05
Isolation
They are isolated from mesenchymal tissues: bone marrow, adipose tissue or peripheral blood.
Bone marrowAdipose tissuePeripheral blood
02/ 05
Controlled stress
They are exposed to controlled stress. The other cells die; Muse Cells survive.
HypoxiaSerum-freeProlonged incubation
03/ 05
Guided migration
After intravenous administration, they home in on damaged sites guided by the S1P (sphingosine-1-phosphate) signal.
S1P signalPreferential homing
04/ 05
Repair
They phagocytose damaged or apoptotic cells and receive signals that trigger their differentiation into the required cell type.
PhagocytosisDifferentiation
05/ 05
Integration
In animal models they integrated into the tissue and remained for months, without tumor formation.
No teratomas in animal modelsNo immunosuppressants in trials
01
Isolation
They are isolated from mesenchymal tissues: bone marrow, adipose tissue or peripheral blood.
02
Controlled stress
They are exposed to controlled stress. The other cells die; Muse Cells survive.
03
Guided migration
After intravenous administration, they home in on damaged sites guided by the S1P (sphingosine-1-phosphate) signal.
04
Repair
They phagocytose damaged or apoptotic cells and receive signals that trigger their differentiation into the required cell type.
05
Integration
In animal models they integrated into the tissue and remained for months, without tumor formation.
DifferencesVS VS VS VS
Compared with other stem cells.
Embryonic stem cells and iPSCs
Pluripotent, with low tumorigenic potential
They differentiate into all three germ layers without forming teratomas in animal models, unlike embryonic stem cells or iPSCs.
iPSCs
No genetic manipulation
They require no reprogramming or genetic manipulation: they are naturally present in the body.
Other mesenchymal cells
Preferential homing to injured tissue
In animal models they homed preferentially to injured areas guided by the S1P signal, with less retention in the lungs.
Allogeneic transplants
No immunosuppressants in clinical trials
They express HLA-G; in clinical trials, donor cells have been given without HLA matching or immunosuppressants.
Research
Solutions for the real world.
Preclinical and clinical research in the heart, brain, neurodegenerative diseases and chronic injuries, with published and ongoing clinical trials.
10+ yearsof research and multiple ongoing clinical trials
Ischemic strokeAcute myocardial infarctionALSAlzheimerNeurodegenerative diseasesChronic injuriesIschemic strokeAcute myocardial infarctionALSAlzheimerNeurodegenerative diseasesChronic injuries
Information provided for informational purposes about lines of scientific and clinical research. It does not replace medical consultation or constitute a promise of results; any treatment requires a medical evaluation and is subject to current health regulations.
The only company in Mexico with Dezawa Muse Cells®.
Exclusive alliance and certification with Muse Cell Innovations, creators of the technology, to bring Dezawa Muse Cells® to healthcare professionals in Mexico.
Manufactured under license by MUSECell Innovations® Singapore Pte LtdDezawa-Verified™ · Certificate of Analysis per vialRegene Global · Official partner in MexicoFrequently asked questions
What people ask us most.
Have another question? Our team will guide you, no strings attached.
Message us on WhatsAppWhat are DEZAWA MUSE CELLS®?
They are pluripotent stem cells naturally present in the body, discovered by Prof. Mari Dezawa at Tohoku University, Japan. They can home in on damaged tissue, respond to damage signals and differentiate into cells of the affected tissue.
What does MUSE stand for?
MUSE stands for Multilineage-differentiating Stress-Enduring cells: cells able to differentiate into multiple lineages and to withstand extreme stress conditions.
How are they different from other stem cells?
They are pluripotent like embryonic stem cells or iPSCs, but did not form teratomas in animal studies and require no genetic reprogramming. In animal models they also homed preferentially to injured areas, with less retention in the lungs than other mesenchymal cells.
Where do they come from?
They are isolated from mesenchymal tissues such as bone marrow, adipose tissue or peripheral blood. When exposed to controlled stress, the other cells die and Muse Cells survive, which allows them to be isolated without prior labeling.
Do they require immunosuppression?
They express HLA-G, a molecule associated with immune tolerance. In published clinical trials, donor cells have been given without HLA matching or immunosuppressants.
How can I access them in Mexico?
Regene Global is Muse Cell Innovations' official partner in Mexico. Write to us and a specialist will guide you; any treatment requires a prior medical evaluation.
Contact
Let's talk about Dezawa Muse Cells®.
Healthcare professionals, researchers, distributors, institutions or partners: our team will guide you on Dezawa Muse Cells® technology and how to access it in Mexico.
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