Dezawa Muse Cells®: what they are and how they differ from other stem cells

In 2007, in Prof. Mari Dezawa's laboratory at Tohoku University, Japan, something appeared that nobody was looking for: a group of cells, hidden among mesenchymal cells, able to withstand severe stress and differentiate into multiple lineages.

In 2010 the finding was formalized: they were described as SSEA-3-positive cells able to differentiate into cells of all three germ layers. In animal models they did not form teratomas. Today we know them as Muse Cells.

01What does MUSE stand for?

MUSE stands for Multilineage-differentiating Stress-Enduring cells: cells able to differentiate into multiple lineages and to withstand extreme stress conditions, such as hypoxia, serum deprivation or prolonged incubation.

02How they act in the body

1. 1IsolationThey are isolated from mesenchymal tissues: bone marrow, adipose tissue or peripheral blood.
2. 2Targeted homingIn preclinical models they home in on damaged tissue, guided by the S1P (sphingosine-1-phosphate) signal.
3. 3Response to damageThey respond to signals from injured tissue and can differentiate into cells of the affected tissue.
4. 4IntegrationPreclinical studies have observed their integration into damaged tissue; their safety and efficacy are still being evaluated in clinical trials.

03Compared with other stem cells

04From Japan to Mexico

Muse Cell Innovations introduced the technology as DEZAWA MUSE CELLS™, in honor of their discoverer, with a licensed manufacturing method. Today, Regene Global is Muse Cell Innovations' official partner in Mexico and brings this technology to physicians and patients across the country.

This article is for informational and educational purposes and does not replace a physician’s evaluation. Results of any treatment vary from patient to patient.